GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | NCF1C | chr7:74572446-74587759:- | 0.09 | 3.85 | 0.000126 | Body mass index |
| BRCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | PMS2L3 | chr7:75137070-75157418:- | -0.39 | -13.39 | 6.6E-38 | Body mass index |
| BRCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | POM121C | chr7:75046066-75115568:- | -0.19 | -5.16 | 2.89E-7 | Body mass index |
| BRCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | SPDYE5 | chr7:75124299-75133627:+ | 0.12 | 3.44 | 0.000605 | Body mass index |
| BRCA | cis | rs1167827 | 1 | rs1167827 | chr7:75163169 | STAG3L1 | chr7:74988447-75026250:+ | -0.3 | -8.46 | 8.78E-17 | Body mass index |
| BRCA | cis | rs757978 | 1 | rs11681497 | chr2:242344333 | SEPT2 | chr2:242254723-242293439:+ | 0.37 | 6.8 | 1.76E-11 | Chronic lymphocytic leukemia |
| BRCA | cis | rs2066819 | 1 | rs116849218 | chr12:56683975 | COQ10A | chr12:56660642-56664748:+ | -0.29 | -3.95 | 8.18E-5 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs116849218 | chr12:56683975 | RPS26 | chr12:56435686-56438005:+ | -0.29 | -3.75 | 0.00019 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs116849218 | chr12:56683975 | SLC39A5 | chr12:56623820-56631627:+ | -0.25 | -3.61 | 0.000316 | Psoriasis vulgaris |
| BRCA | cis | rs11685222 | 1 | rs11685222 | chr2:120748571 | TMEM177 | chr2:120436743-120481191:+ | -0.34 | -6.56 | 8.38E-11 | Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) |
| BRCA | cis | rs4629203 | 1 | rs11685475 | chr2:40665795 | SLC8A1 | chr2:40339287-40739575:- | -0.1 | -3.51 | 0.000458 | Obesity-related traits |
| BRCA | cis | rs4372836 | 1 | rs11688129 | chr2:28952581 | TRMT61B | chr2:29072690-29093175:- | 0.25 | 6.17 | 9.72E-10 | Body mass index |
| BRCA | cis | rs4372836 | 1 | rs11690423 | chr2:28951537 | TRMT61B | chr2:29072690-29093175:- | 0.25 | 6.09 | 1.56E-9 | Body mass index |
| BRCA | cis | rs7578199 | 1 | rs11695244 | chr2:242176706 | SEPT2 | chr2:242254723-242293439:+ | -0.15 | -3.68 | 0.000244 | Chronic lymphocytic leukemia |
| BRCA | cis | rs11696845 | 1 | rs11696845 | chr20:43371320 | KCNK15 | chr20:43374488-43379666:+ | 0.13 | 4.67 | 3.42E-6 | Obesity-related traits |